Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species

Author: Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab

ijeab doi crossref DOI: 10.22161/ijeab/1.4.43

Keyword: Acremonium, Aspergillus, Cephalosporin C, Batch fermentation, Mutagenesis.

Abstract: Three species of Aspergillus (A. niger, A. flavus, A. nidulans) and two species of Acremonium (A. furcatum and A. kiliense) were tested for their potential to biosynthesis of cephalosporin-C (CPC) in batch mode of cultivation before and after mutagenesis. The effects of different ingredients of the medium on CPC yield were thoroughly investigated. Results manifested that sucrose 30 mg ml-1, DL methionine 3mg mL-1 and ammonium sulphate 7.5 mg mL-1 were most appropriate for maximum harvest of antibiotic. Mutants were achieved by exposing fungal cultures to 400 µg mL-1 of ethyl methane sulphonate (EMS) for 1 hour.

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Cite this Article:

MLA

Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab et al."Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species". International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878),vol 1, no. 4, 2016, pp.0926-0933 AI Publications doi:10.22161/ijeab/1.4.43

APA

Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab, P.(2016).Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species. International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).1(4), 0926-0933.10.22161/ijeab/1.4.43

Chicago

Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab, P.(2016).Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species. International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).1(4), pp.0926-0933.

Harvard

Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab. 2016."Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species". International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).1(4):0926-0933.Doi:10.22161/ijeab/1.4.43

IEEE

Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab."Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species", International Journal of Environment Agriculture and Biotechnology,vol.1,no. 4, pp.0926-0933,2016.

Bibtex

@article { zill-e-humabilal2016comparative,
title={Comparative Studies on Cephalosporin C biosynthesis by Aspergillus and Acremonium Species},
author={Zill-e-Huma Bilal, Adeela Yousaf, Iffat Siddique, Arusa Aftab , R},
journal={International Journal of Environment Agriculture and Biotechnology},
volume={1},
year= {2016} ,
}