3D Arbitrary Channel Fabrication for Lab on a Chip Applications using Chemical Decomposition

3D Arbitrary Channel Fabrication for Lab on a Chip Applications using Chemical Decomposition ( Vol-2,Issue-5,September - October 2017 )

Author: Jahan Zeb Gul, Jinhee Na, Kyung Hyun Choi

ijeab doi crossref DOI: 10.22161/ijeab/2.5.9

Keyword: Micro Channel, Arbitrary, 3D Micro Channel, Lab on a Chip.

Abstract: This article demonstrate a simple method to use of three-dimensionally (3D) printed molds that are chemically decomposable for rapid fabrication of complex and arbitrary microchannel geometries. These complex microchannel are unachievable through existing soft lithography techniques. The molds are printed directly from hand held 3D printing pen that can print in midair, making rapid prototyping of microfluidic devices possible in hours. PLA based copper filament is used to print the arbitrary channels. The printed channels are then placed inside PDMS and PDMS is cured. The cured sample is then immersed in chemical solution (Acetic Acid + Sodium Chloride+ Hydrogen peroxide), which decomposes the PLA based copper channel thus leaving an empty channel inside the PDMS block. This method enable precise control of various device geometries, such as the profile of the channel cross-section and variable channel diameters in a single device.


[1] P. Neuži, S. Giselbrecht, K. Länge, T. J. Huang, and A. Manz, “Revisiting lab-on-a-chip technology for drug discovery,” Nat. Rev. Drug Discov., vol. 11, no. 8, pp. 620–632, Aug. 2012.
[2] H. A. Stone and S. Thutupalli, “Microfluidics: For a few drops more,” Nat. Phys., vol. 10, no. 2, pp. 87–88, Jan. 2014.
[3] L. Vinet and A. Zhedanov, “A ‘missing’ family of classical orthogonal polynomials,” Rev. Mod. Phys., vol. 77, no. 3, pp. 977–1026, Nov. 2010.
[4] D. J. Beebe, G. a Mensing, and G. M. Walker, “Physics and Applications of Microfluidics in Biology,” Annu. Rev. Biomed. Eng., vol. 4, no. 1, pp. 261–286, Aug. 2002.
[5] S. K. Sia and G. M. Whitesides, “Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies,” Electrophoresis, vol. 24, no. 21, pp. 3563–3576, Nov. 2003.
[6] E. K. Sackmann, A. L. Fulton, and D. J. Beebe, “The present and future role of microfluidics in biomedical research,” Nature, vol. 507, no. 7491, pp. 181–189, Mar. 2014.
[7] S. N. Bhatia and D. E. Ingber, “Microfluidic organs-on-chips,” Nat. Biotechnol., vol. 32, no. 8, pp. 760–772, Aug. 2014.
[8] D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev., vol. 39, no. 3, p. 1153, 2010.
[9] S. K. W. Dertinger, D. T. Chiu, N. L. Jeon, and G. M. Whitesides, “Generation of Gradients Having Complex Shapes Using Microfluidic Networks,” Anal. Chem., vol. 73, no. 6, pp. 1240–1246, Mar. 2001.
[10] K. Ren, Y. Chen, and H. Wu, “New materials for microfluidics in biology,” Curr. Opin. Biotechnol., vol. 25, pp. 78–85, Feb. 2014.
[11] K. Ren, J. Zhou, and H. Wu, “Materials for Microfluidic Chip Fabrication,” Acc. Chem. Res., vol. 46, no. 11, pp. 2396–2406, Nov. 2013.
[12] C.-W. Tsao, “Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production,” Micromachines, vol. 7, no. 12, p. 225, Dec. 2016.
[13] A. Alrifaiy, O. A. Lindahl, and K. Ramser, “Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering,” Polymers (Basel)., vol. 4, no. 4, pp. 1349–1398, Jul. 2012.
[14] M. Figurova, D. Pudis, P. Gaso, and I. Cimrak, “PDMS microfluidic structures for LOC applications,” in 2016 ELEKTRO, 2016, pp. 608–611.
[15] J. Friend and L. Yeo, “Fabrication of microfluidic devices using polydimethylsiloxane,” Biomicrofluidics, vol. 4, no. 2, p. 26502, Jun. 2010.
[16] Q. Zhang and R. H. Austin, “Applications of Microfluidics in Stem Cell Biology,” Bionanoscience, vol. 2, no. 4, pp. 277–286, Dec. 2012.
[17] H. Wu, T. W. Odom, D. T. Chiu, and G. M. Whitesides, “Fabrication of Complex Three-Dimensional Microchannel Systems in PDMS,” J. Am. Chem. Soc., vol. 125, no. 2, pp. 554–559, Jan. 2003.
[18] D. P. Parekh, C. Ladd, L. Panich, K. Moussa, and M. D. Dickey, “3D printing of liquid metals as fugitive inks for fabrication of 3D microfluidic channels,” Lab Chip, vol. 16, no. 10, pp. 1812–1820, 2016.
[19] C. Chen, B. T. Mehl, A. S. Munshi, A. D. Townsend, D. M. Spence, and R. S. Martin, “3D-printed microfluidic devices: fabrication, advantages and limitations—a mini review,” Anal. Methods, vol. 8, no. 31, pp. 6005–6012, 2016.
[20] G. Gaal, M. Mendes, T. P. De Almeida, M. H. O. Piazzetta, Â. L. Gobbi, A. Riul, and V. Rodrigues, “Sensors and Actuators B : Chemical Simplified fabrication of integrated microfluidic devices using fused deposition modeling 3D printing,” Sensors Actuators B. Chem., vol. 242, pp. 35–40, 2017.
[21] G. Gaal, M. Mendes, T. P. de Almeida, M. H. O. Piazzetta, Â. L. Gobbi, A. Riul, and V. Rodrigues, “Simplified fabrication of integrated microfluidic devices using fused deposition modeling 3D printing,” Sensors Actuators B Chem., vol. 242, pp. 35–40, Apr. 2017.
[22] S. Waheed, J. M. Cabot, N. P. Macdonald, T. Lewis, R. M. Guijt, B. Paull, and M. C. Breadmore, “3D printed microfluidic devices: enablers and barriers,” Lab Chip, vol. 16, no. 11, pp. 1993–2013, 2016.
[23] S. Mohanty, L. B. Larsen, J. Trifol, P. Szabo, H. V. R. Burri, C. Canali, M. Dufva, J. Emnéus, and A. Wolff, “Fabrication of scalable and structured tissue engineering scaffolds using water dissolvable sacrificial 3D printed moulds,” Mater. Sci. Eng. C, vol. 55, pp. 569–578, Oct. 2015.
[24] J. Hammer, L.-H. Han, X. Tong, and F. Yang, “A Facile Method to Fabricate Hydrogels with Microchannel-Like Porosity for Tissue Engineering,” Tissue Eng. Part C Methods, vol. 20, no. 2, pp. 169–176, Feb. 2014.
[25] D. J. Beebe, J. S. Moore, J. M. Bauer, Q. Yu, R. H. Liu, C. Devadoss, and B.-H. Jo, “Functional hydrogel structures for autonomous flow control inside microfluidic channels : Abstract : Nature,” Nature, vol. 404, no. 6778, pp. 588–590, 2000.
[26] S. Li, Y. Liu, Y. Li, C. Liu, Y. Sun, and Q. Hu, “A novel method for fabricating engineered structures with branched micro-channel using hollow hydrogel fibers,” Biomicrofluidics, vol. 10, no. 6, p. 64104, Nov. 2016.
[27] M. D. Raj and R. Rengaswamy, “Investigating Arrangement of Composite Drops in Two-Dimensional Microchannels Using Multiagent Simulations: A Design Perspective,” Ind. Eng. Chem. Res., vol. 54, no. 43, pp. 10835–10842, Nov. 2015.
[28] M. J. A. Khan, M. R. Hasan, and M. A. H. Mamun, “Flow Behavior and Temperature Distribution in Micro-Channels for Constant Wall Heat Flux,” Procedia Eng., vol. 56, pp. 350–356, 2013.
[29] G. Puccetti, B. Pulvirenti, and G. L. Morini, “Experimental Determination of the 2D Velocity Laminar Profile in Glass Microchannels using μPIV,” Energy Procedia, vol. 45, pp. 538–547, 2014.
[30] X. Guo, C. Huang, A. A. Alexeenko, and J. P. Sullivan, “Numerical and Experimental Study of Gas Flows in 2D and 3D Microchannels,” in ASME 5th International Conference on Nanochannels, Microchannels, and Minichannels, 2007, pp. 393–400.

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