Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats ( Vol-2,Issue-6,November - December 2017 )
Author: Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet
DOI: Keyword: Anacyclus valentinus, Arthritis, diclofenac sodium, Freund's complete adjuvant, paw volume
Abstract: Anacyclus valentinus L. is a common annual plant in Algeria, known for her various therapeutic effects. In addition, the plant is used as a food condiment. We reported our investigations on the chemical compositions and the antiarthritic activity of methanolic extract of A. valentinus (MEAV). The polyphenol extraction by maceration with methanol (80%) gave yields of 17.82%. The identification by LC-MS and colorimetric assays revealed the wealth of methanolic extracts on phenolic compounds including flavonoids (52.15 mg Equ/g) and lactones. Acute oral toxicity of extract was performed in line with OECD guidelines and the lethal dose 50 was assessed greater than 2500 mg/Kg. Regarding the anti-arthritic power, rheumatoid arthritis was induced by Freund's adjuvant in rats. The methanolic extract of A. valentinus presented a largest effect with weight gain, an arthritic score, thymus indices; spleen and serum parameters close to those of the control. The extract also inhibited edema and restored cartilage structure.
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[31] S. Dubucquoi & S.Fily-Nalewajk (2008). Prise en charge de la polyarthrite rhumatoïde en 2008 : la biologie peut-elle répondre aux attentes des cliniciens ? Rev Fr Laboratoires ;404:51-7.
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[33] E.D. Harris (1990). Rheumatoid arthritis. Pathophysiology and implications for therapy. N Eng J Med.322(18): 1277-89
[34] K. Batanouny (2005). Guide to Medicinal Plants in North Africa. Centre for Mediterranean Cooperation. International Union for Conservation of Nature and Natural Resources, 1: 35-37.
[35] G. Benitez, M.R. Gonzalez-Tejero and J. Molero-Mesa (2010). Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): Ethnopharmacological synthesis. J. Ethnopharm., 129: 87–105.
[36] Y.K. Kim, Y.S. Kim, S.U. Choi, S.Y. Ryu (2004). Isolation of flavonol rhamnosides from Loranthus tanakae and cytotoxic effect of them on human tumor cell lines. Arch. Pharm. Res. 27:44 - 47.
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[2] P. Patel, D. Patel, N. Patel (2012). Experimental investigation of anti-rheumatoid activity of Pleurotus sajorcaju in adjuvant-induced arthritic rats. Chin J Nat Med; 10:0269–74.
[3] D.K. Praveen, M. Suchita (2013). Herbal sources of anti-arthritic potential: a comprehensive review. Int. J. Pharm. 4, 88–92.
[4] N.J. Gullick, D.L. Scott (2012). Drug therapy of inflammatory arthritis. Clin Med; 12:357-63.
[5] M. Rajkumar, C.R. Harish, K. Asres, C. Veeresham (2008). Toddalia asiatica (Linn) Lam-A comprehensive review. Pharmacogn Rev; 2:386-97.
[6] K. Maiza, R. A. Brac de la Perrière, V. Hammiche Pharmacopée traditionnelle saharienne : Sahara septentrional. In: Schröder, E., Balansard, G., Cabalion, P., Fleurentin, J., Mazars, G. (1993). Médicaments et aliments : L’approche ethnopharmacologique. Actes du 2ème Colloque Européen d’Ethnopharmacologie et de la 11ème Conférence internationale d’Ethnomédecine. Heidelberg, pp. 169-171.
[7] P.H. Julve (2015). ff- Baseflor. Index botanique, écologique et chorologique de la flore de France.
[8] A.L. Tadjeddine, N. Kambouche, H.Medjdoub, B. Meddah, A. Dicko et al., (2013). Antidiabetic effect of Anacyclus valentines L. aqueous extract in normoglycemic and streptozotocin induced-diabetic rats. American Journal of Phytomedicine and Clinical Therapeutics. AJPCT 5 424-43.
[9] I. Hacheimi and O. Kadi (2009). Effet de l’extrait aqueux de L’Anacyclus Valentinus l sur le cholestérol.
[10] C. Selles, M.A. Dib, N. Djabou, F. Beddou, A. Muselli, B. Tabti, J. Costa and B. Hammouti (2013). Antimicrobial activity and evolution of the composition of essential oil from Algerian Anacyclus pyrethrum L. through the vegetative cycle, Natural Product Research, 11:46.
[11] K. Boungab, A. Tadjeddine , L. Belabid, Z. Fortas, F. Lazrag (2011) Antifungal activity of extracts of Anacyclus valentinus L. on phytopathogenic fungi. 4th International Conference on Alternative Methods in Crop Protection. Evolution of French and European regulatory frameworks. Innovative new means and strategies, New Century, Lille, France. 230- 238.
[12] G. Harald (1978). Comparative phytochemistry and systematics of Anacyclus. Biochemical Systematics and Ecology, 1978; 6: 11 –17.
[13] Sawsan Abuhamdah, Rushdie Abuhamdah, Suleiman Al-Olimat and Paul Chazot (2013). Phytochemical Investigations and Antibacterial Activity of Selected Medicinal Plants from Jordan. European Journal of Medicinal Plants 3(3): 394-404.
[14] N. Boizot and J-P. Charpentier (2006). Méthode rapide d’évaluation du contenu en composés phénoliques des organes d’un arbre forestier. Cah. Tech. INRA. N°. special. pp. 79-82.
[15] V. Dewanto, X. Wu, K.K. Adom, R.H. Liu (2002). Thermal Processing Enhances the nutritional Value of Tomatoes by increasing total antioxidant activity. J. Agric. Food Chem. 50 : 3010–3014.
[16] H. Khan, M. Saeed, A.U.H. Gilani, M.A. Khan, A. Dar, I. Khan (2010). The antinociceptiveactivity of Polygonatumverticillatum rhizomes in pain models. J Ethnopharmacol, 127(2):521 –527.
[17] E. Woode, E.Boakye-Gyasi, C.A. Danquah, C. Ansah, M. Duwiejua (2009). Anti-arthritic effects of Palisota hirsuta K. Schum. Leaf extract in Freund’s adjuvant arthritis in rats. International journal of pharmacology. 5 (3): 181-190.
[18] Abdel-Moein N.M., Abdel-Moniem E.A., Mohamed D.A. and Hanfy E.A. (2011). Evaluation of the anti-inflammatory and anti-arthritic effects of some plant extracts. grasas y aceites, 62 (4). 365-374.
[19] H. Gerhard Vogel (2002). Drug discovery and evaluation, pharmacological assays, Second edition, p 802- 803.
[20] L.L. Zhang, W. Wei, S.X. Yan, X.Y. Hu, W.Y. Sun (2004). Therapeutic effects of glucosides of Cheanomeles speciosa on collagen-induced arthritis in mice. Acta Pharmacologica Sinica 2004; 25: 1495–1501.
[21] P.D. Eckersall & A.S. Nash (1983). Isoenzymes of canine plasma alkaline phosphatase : an investigation using isoelectric focusing and related to diagnosis, Res. Vet. Sci., 1983, 34, 310-314.
[22] Karnati Mamatha, Chandra Rodda H., Veeresham Ciddi, Kishan Bookya (2013). Anti arthritic activity of root bark of Oroxylum indicum (L.) vent against adjuvant induced arthritis. Pharmacognosy Research ; Vol 5 (2) : 121 – 128 .
[23] S.R. Yend, V.D. Sannapuri, N.S. Vyawahare, U.N. Harle (2010). Antirheumatoid activity of aqueous extract of Piper nigrum on Freund’s Adjuvant induced arthritis in rats. Int J Pharma Sci Res. 1(1): 129-33.
[24] A.D.Kshirsagar, P.V. Panchal, U.N. Harle, R.K. Nanda, H.M. Shaikh (2014). Antiinflammatory and antiarthritic activity of anthraquinone derivatives in rodents.
Int. J. Inflamm.12690596.
[25] R. Roubenoff, R.A. Roubenoff, J.G. J.J. Cannon, Kehayias, B. Zhuang, B. Dawson-Hughes, et al. (1994). Rheumatoid cachexia: cytokine driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest; 93:2379–86.
[26] E. Brunet-Guedj, B. Brunet, J. Girardier, B. Moyen (2006). Medecine du sport. 7th ed. Masson. pp. 263–7.
[27] A.C. Issekutz, K. Sapru (2008). Modulation of adjuvant arthritis in the rat by 2 methoxyestradiol: an effect independent of an anti-angiogenic action. Int. Immunopharmacol. 8, 708–716.
[28] C. Gebhard, S.F. Stämpfli, C.E. Gebhard et al. (2009). Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis. Basic Res Cardiol;104 (3):285-94.
[29] D. Ricklin, , G. Hajishengallis, et al. (2010). "Complement: a key system for immune surveillance and homeostasis." Nat Immunol 11(9): 785-797.
[30] A. Akhtar, Deshmukh A.A., Raut C.G., Somkuwar A.P., & Bhagat S.S. (2012). Prallethrin induced serum biochemical changes in Wistar rats. Pesticide Biochemistry and Physiology, 102: 160-168.
[31] S. Dubucquoi & S.Fily-Nalewajk (2008). Prise en charge de la polyarthrite rhumatoïde en 2008 : la biologie peut-elle répondre aux attentes des cliniciens ? Rev Fr Laboratoires ;404:51-7.
[32] M.B. Pepys, G.M. Hirschfield (2003). C-reactive protein: a critical update, Journal of Clinical Investigation 111:1805–1812.
[33] E.D. Harris (1990). Rheumatoid arthritis. Pathophysiology and implications for therapy. N Eng J Med.322(18): 1277-89
[34] K. Batanouny (2005). Guide to Medicinal Plants in North Africa. Centre for Mediterranean Cooperation. International Union for Conservation of Nature and Natural Resources, 1: 35-37.
[35] G. Benitez, M.R. Gonzalez-Tejero and J. Molero-Mesa (2010). Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): Ethnopharmacological synthesis. J. Ethnopharm., 129: 87–105.
[36] Y.K. Kim, Y.S. Kim, S.U. Choi, S.Y. Ryu (2004). Isolation of flavonol rhamnosides from Loranthus tanakae and cytotoxic effect of them on human tumor cell lines. Arch. Pharm. Res. 27:44 - 47.
[37] Bahmani Mahmoud, Shirzad Hedayatollah, Majlesi Maedeh et al. (2014). A review study on analgesic applications of Iranian medicinal plants. Asian Pac J Trop Med; 7(Suppl 1): S43-S53.
[38] G. Odontuya, J. R. S. Hoult, and P. J. Houghton (2005). Structure-activity relationship for anti-inflammatory effect of luteolin and its derived glycosides. Phytother. Res. 19: 782 - 786.
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