Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats

DOI: 10.22161/ijeab/2.6.31

Keyword: Anacyclus valentinus, Arthritis, diclofenac sodium, Freund's complete adjuvant, paw volume

Abstract: Anacyclus valentinus L. is a common annual plant in Algeria, known for her various therapeutic effects. In addition, the plant is used as a food condiment. We reported our investigations on the chemical compositions and the antiarthritic activity of methanolic extract of A. valentinus (MEAV). The polyphenol extraction by maceration with methanol (80%) gave yields of 17.82%. The identification by LC-MS and colorimetric assays revealed the wealth of methanolic extracts on phenolic compounds including flavonoids (52.15 mg Equ/g) and lactones. Acute oral toxicity of extract was performed in line with OECD guidelines and the lethal dose 50 was assessed greater than 2500 mg/Kg. Regarding the anti-arthritic power, rheumatoid arthritis was induced by Freund's adjuvant in rats. The methanolic extract of A. valentinus presented a largest effect with weight gain, an arthritic score, thymus indices; spleen and serum parameters close to those of the control. The extract also inhibited edema and restored cartilage structure.

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Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet et al."Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats". International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878),vol 2, no. 6, 2017, pp.3025-3032 AI Publications doi:10.22161/ijeab/2.6.31

Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet, P.(2017).Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats. International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).2(6), 3025-3032.10.22161/ijeab/2.6.31

Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet, P.(2017).Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats. International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).2(6), pp.3025-3032.

Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet. 2017."Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats". International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).2(6):3025-3032.Doi:10.22161/ijeab/2.6.31

Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet."Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats", International Journal of Environment Agriculture and Biotechnology,vol.2,no. 6, pp.3025-3032,2017.

@article { khadidjasidelarbi2017chemical,
title={Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats},
author={Khadidja Side Larbi, Boumediene Meddah, Hamza Belkhodja, Asmaa Belmimoun, Khaled Slimani, Pascal Sonnet , R},
journal={International Journal of Environment Agriculture and Biotechnology},
volume={2},
year= {2017} ,
}