Cancer Therapy with CRISPR/Cas9: Prospects and Challenges

DOI: 10.22161/ijeab.63.16

Keyword: Advance therapy; CRISPER; Cas9; Genome engineering; Cancer models.

Abstract: Globally, Cancer is believed to be second biggest reason of mortality and one of the significant social as well as economic liabilities. Despite our advance at molecular level in comprehension of cancer, more therapeutic tools and tactics are needed to exploit this advance. The CRISPER/Cas9 genome modifying approach has lately appeared as an effective cancer therapy method due to its high accuracy and efficiency. CRISPER/Cas9 has enormous clinical potential in discovering new targets for cancer treatment and also to dismember genetic-chemical interaction thus helping us to understand the response of tumor to the treatment by drugs. Additionally, Cas9/CRISPER can also be used in cancer immunotherapeutic applications by engineering immune cells and oncolytic viruses. Perhaps the most important therapeutic application of Cas9/CRISPER is its ability to edit genes with great precision both in animal models and humans. In this review, we will debate and explore some important concerns of using CRISPER/Cas9 in remedial settings and some vital hurdles that are needed to overcome before it is used for a clinical trial for a polygenic and complex ailment like cancer.

Article Info: Received: 04 Apr 2021; Received in revised form: 21 May 2021; Accepted: 01 Jun 2021; Available online: 17 Jun 2021

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Page No: 143-152

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Muhammad Fahad Chaudhary, Unsa Saleem, Samia Khan, Rabiya Khan, Muhammad Asim, Fakhra Azam, Mariam Sharif, Zainab, Ali Abbas Dilawar, Muhammad Jehanzaib et al."Cancer Therapy with CRISPR/Cas9: Prospects and Challenges". International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878),vol 6, no. 3, 2021, pp.143-152 AI Publications doi:10.22161/ijeab.63.16

Muhammad Fahad Chaudhary, Unsa Saleem, Samia Khan, Rabiya Khan, Muhammad Asim, Fakhra Azam, Mariam Sharif, Zainab, Ali Abbas Dilawar, Muhammad Jehanzaib, P.(2021).Cancer Therapy with CRISPR/Cas9: Prospects and Challenges. International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).6(3), 143-152.10.22161/ijeab.63.16

Muhammad Fahad Chaudhary, Unsa Saleem, Samia Khan, Rabiya Khan, Muhammad Asim, Fakhra Azam, Mariam Sharif, Zainab, Ali Abbas Dilawar, Muhammad Jehanzaib, P.(2021).Cancer Therapy with CRISPR/Cas9: Prospects and Challenges. International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).6(3), pp.143-152.

Muhammad Fahad Chaudhary, Unsa Saleem, Samia Khan, Rabiya Khan, Muhammad Asim, Fakhra Azam, Mariam Sharif, Zainab, Ali Abbas Dilawar, Muhammad Jehanzaib. 2021."Cancer Therapy with CRISPR/Cas9: Prospects and Challenges". International Journal of Environment Agriculture and Biotechnology(ISSN: 2456-1878).6(3):143-152.Doi:10.22161/ijeab.63.16

Muhammad Fahad Chaudhary, Unsa Saleem, Samia Khan, Rabiya Khan, Muhammad Asim, Fakhra Azam, Mariam Sharif, Zainab, Ali Abbas Dilawar, Muhammad Jehanzaib."Cancer Therapy with CRISPR/Cas9: Prospects and Challenges", International Journal of Environment Agriculture and Biotechnology,vol.6,no. 3, pp.143-152,2021.

@article { muhammadfahadchaudhary2021cancer,
title={Cancer Therapy with CRISPR/Cas9: Prospects and Challenges},
author={Muhammad Fahad Chaudhary, Unsa Saleem, Samia Khan, Rabiya Khan, Muhammad Asim, Fakhra Azam, Mariam Sharif, Zainab, Ali Abbas Dilawar, Muhammad Jehanzaib , R},
journal={International Journal of Environment Agriculture and Biotechnology},
volume={6},
year= {2021} ,
}