Determination of Phosphate in Water Samples using Antiulcer drugs as Spectrophotometric reagents

DOI: 10.22161/ijeab/2.6.68

Abstract:
Omeprazole (OMZ) and lansoprazole (LNZ) was examined as spectrophotometric reagents for the detection of phosphate in presence 3-Methyl-2-benzothiazolinone hydrazone hydrochloride hydrate (MBTH) as electrophilic coupling reagent. The medium used for the reaction was acidic. The blue colour that was produced indicated that the MBTH-OMZ/LNZ method had the maximum absorbance at 640 nm. Beer's law is verified by the method within the range of 100-1600 ng mL-1 and 200-1800 ng mL-1for OMZ, LNZ, respectively. The blue colour formed at room temperature (270C) remained stable for 24 hours. The molar absorptivity with LNZ and PNZ was found to be 4.98x104 and 3.76 x104. The interference studies with 8 cations/ anions were carried out and the results indicated that the method was free from the common interfering ions. The developed method showed good reproducibility and can be sufficiently applied for the detection of phosphate in water samples.

Keywords:
Antiulcer drugs, Phosphate, Spectrophotometry, Water samples

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