In Vitro Evaluation of Cholesterol Lowering Properties of Plant Extract, Trigonella Foenum Graecum L.

DOI: 10.22161/ijeab.94.17

Abstract:
Atherosclerosis is a disorder that causes the inner lining of arterial walls to accumulate lipids, cholesterol, and other chemicals. This restriction of blood flow results in high cholesterol, high blood pressure, high triglycerides, diabetes, obesity, and associated cardiovascular disorders. The current study sought to evaluate the ability of plant extract Trigonella foenum graecum ability to decrease cholesterol in vitro. Plant extracts were used at varying doses to block the activities of enzymes pancreatic lipase, glucose-6-phosphate dehydrogenase, and malic dehydrogenase. The extracts were then sequentially extracted using solvents including methanol, hexane, ethyl acetate, ethanol, and dichloromethane. According to the findings, the ethanol extract had the greatest significant hypolipidemic impact by reducing enzyme activities, and this was followed by the extracts of hexane, dichloromethane, and methanol. The ethyl acetate extracts showed the lowest hypolipidemic activity. These findings imply that the administration of several Trigonella foenum graecum plant extracts may have unique potential cholesterol-lowering qualities for reducing fat absorption via inhibiting pancreatic lipase.

Keywords:
Fenugreek, pancreatic lipase, glucose-6-phosphate dehydrogenase, malic dehydrogenase, lipid metabolism.

Article Info:
Received: 27 Jun 2024; Received in revised form: 22 Jul 2024; Accepted: 31 Jul 2024; Available online: 08 Aug 2024

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